I Have What?! Understanding MTHFR the Folate Cycle and Down Syndrome
This talk was given at the Mission Possible cruise in 2014.
Norman Schwartz, MD, Integrative Functional Medicine
Advanced maternal age is a major risk factor for trisomy 21, though most children with Down syndrome are born to mothers less than 30 years old. Research by Jill James PhD and other have established that abnormal folate metabolism is present in a significant percentage of mothers of children with Down Syndrome. This may be explained, in part, by altered methylation patterns due to variations in the gene methylenetetrahydrofolate reductase (MTHFR) that can lead to DNA changes and may be a risk factor for maternal meiotic nondisjunction and Down syndrome in younger mothers.
Dr. Schwartz will present a scientific, evidence-based review of methylation and the folate cycle and what has been proven to work or holds significant promise for assessment and treatment. The methylation/folate cycle is a fundamental biological control system that regulates gene stability and expression, hormone and neurotransmitter recycling, detoxification and inflammation.He will also review the health risks for a mother with a Down syndrome child, including: depression, heart disease, Alzheimer’s, and cancer and way to minimize these risks for optimal health.
Dr. Norm Schwartz MD is an Integrative Functional Medicine specialist with extensive experience in treating children and adults with Down syndrome and individuals with complex, chronic medical problems. Formerly medical director of Integrative Medicine at Wheaton Franciscan Health Care he is now in private practice in Milwaukee, Wisconsin, USA.
Mission Possible has now been renamed Rosalie's Cruises & Tours