Taken from: Nutritional Intervention: talking about health + Down syndrome with Gabi Giacomin​

Individuals with Down Syndrome have below normal levels of Folate, which increases with age. Erythrocyte macrocytosis (large red blood cells) is more common in children with DS due to alterations in the methylation cycle. Low homocyteine levels and a high risk of folate trapping can be avoided through intervention with Folinic acid. This form of folate is more efficiently absorbed and available for folate dependent reactions.


Taken from: Entrain : The effect of folinic acid in Down Syndrome

Various anomalies in the use of vitamin B (B1, B6…) are well known to have an effect on intellectual performances on patients, carriers or non-carriers of Down syndrome. In patients with Down Syndrome, there is a functional disorders in vitamin B9 which triggers several cellular anomalies. This is due to the fact that 7 genes involved in the use of this vitamin by the cell (metabolism) are situated on the chromosome 21. 

In 2010 Entrain conducted a study.  It aimed at evaluating the effects of folinic acid treatment on neurological functions on 117 children with Down Syndrome aged from 6 to 30 months. The results revealed a positive effect of the treatment on the psychomotor development of some of the children. 

The results of this study were very interesting. They show that folinic acid is probably useful in cognitive development in young patients with Down Syndrome. The development of children treated with folinic acid is increased by about 9% compared with the children receiving placebo.

Actually, the results show that the children whose intellectual development progresses are those who also receive a thyroid hormone (thyroxin). The evolution in the age of development in that group is 18% higher than in the placebo group. This is a bit unexpected but not illogical: it has been known for a long time that thyroid hormones are useful for brain development in babies.

In therapeutic fields one must always be very prudent. However, given the high tolerance to folinic acid, it appears legitimate to give it, under medical control, to babies with Down Syndrome who are taking thyroid hormones, (this concerns 1/3 of patients) including very young ones.

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