• Katya McCubbing

Oxidative Stress and Epigenetic Alterations in Down Syndrome


Published on May 14, 2013

Dr. Jill James - Professor Of Pediatrics, University Of Arkansas For Medical Sciences/College Of Medicine/Department Of Paediatrics.

Dr. Jill James is the Director of the Metabolic Genomics Laboratory at ACHRI and a collaborator of the Arkansas Center for Birth Defects Research and Prevention. Her research is focused on the understanding of the metabolic and genetic factors that may be mechanistically involved in the aetiology of autism, Down syndrome, and childhood acute lymphoblastic leukaemia (ALL). The Metabolic Genomics team measures plasma levels of metabolites that are predictive of impaired methylation capacity and oxidative stress. In addition, the lab measures genetic polymorphisms that could contribute to an increased risk of oxidative stress and decreased glutathione‐mediated antioxidant defence.

Prof James is the Director of the Metabolic Genomics Laboratory at ACHRI and a collaborator of the Arkansas Center for Birth Defects Research and Prevention. Her research is focused on the understanding of the metabolic and genetic factors that may be mechanistically involved in the etiology of autism, Down syndrome, and childhood acute lymphoblastic leukemia (ALL). The Metabolic Genomics team measures plasma levels of metabolites that are predictive of impaired methylation capacity and oxidative stress. In addition, the lab measures genetic polymorphisms that could contribute to an increased risk of oxidative stress and decreased glutathione-mediated antioxidant defense.

Taken from the DSRF UK Youtube Channel page

#leukaemia #autism #methylation

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